DIAGNOSTIC TEST PANEL 531
Diabetes Mellitus Type 1
Diagnostic test panel for antibodies against GAD, islet cells, insulin, IA-2, and ZnT8. For suspicion of type 1 dependent diabetes (T1D).
Indication
Suspicion of type 1 dependent diabetes (T1DD, previously known as insulin-dependent diabetes mellitus, IDDM).
Clinical background
Type 1 diabetes is due to an autoimmune destruction of the insulin-producing ß-cells in the Langerhans islets in the pancreas. The destruction is probably triggered by one or more unknown environmental factors which in genetically predisposed individuals starts a slowly progressive process. Only when the number of viable b-cells is below a critical threshold, does hyperglycaemia with the accompanying symptoms arise. Islet cell antibodies are detected with IIF on monkey pancreas and the analysis is positive in 70-90% of T1DD patients at the time of the diagnosis. The antibodies react with glutamic acid decarboxylase (GAD), insulinom-associated protein 2 (IA-2), insulin and probably other unknown antigens. Specific antibodies against GAD, IA2 and insulin can be detected with immunoprecipitation. So far all prospective studies of relatives of type 1 diabetes patients have shown that the combination of two or more antibodies give a higher positive predictive value than only one antibody. Up to 90% of the asymptomatic antibody carriers will be insulin-dependent within 6 years.
Tests included in panel
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How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 1 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Samples can be sent at room temperature to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
