DIAGNOSTIC TEST 090

Islet Cell Antibodies

Diagnostic test for antibodies against islet cells. For suspicion of risk of developing type 1 diabetes (T1D).

Indication

Suspicion of type 1 diabetes (T1D)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: room temperature

Method

Indirect immunofluorescence (IIF)

Reference interval

<1:5 negative

Result

Results are reported as negative or positive with a titer.

Interpretation

Approximately 70-90% of patients diagnosed with T1D, are positive for antibodies against Islet cells. Antibodies can be detected several years before diagnosis and are a strong predictor of future development of insulin-dependent diabetes mellitus (IDDM).

Islet cell antibodies comprise of a heterogeneous group of antibodies that are directed against glutamic acid decarboxylase (GAD65), tyrosine phosphatase-related islet cell antigen 2 (IA-2), zinc transport protein ZnT8, and other untill now unknown antigens.

References

  • Hill TG, Hill DJ. Int J Mol Sci. 2024 The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. PMID: 38612880
  • Joglekar MV et al. Lancet Diabetes Endocrinol. 2024 Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores. PMID: 38797187
  • Phillip M et al. Diabetes Care. 2024. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. PMID: 38912694

Included in these panels

Need pricing information?

Get a quote

How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-19