DIAGNOSTIC TEST 957

KLHL11 Antibodies (IgG)

Diagnostic test for antibodies against KLHL11. For suspicion of paraneoplastic cerebellar encephalitis.

Indication

Suspicion of paraneoplastic cerebellar encephalitis

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

Serum

  • <1/1000 negative

CSF

  • <1/100 negative

Result

Results are reported as negative, borderline, or positive.

Interpretation

Kelch-like protein 11 (KLHL11) is a subunit of the E3 ubiquitin ligase complex. IgG antibodies against KLHL11 have been reported in paraneoplastic cerebellar encephalitis.

References

  • Maudes E et al. Neurol Neuroimmunol Neuroinflamm. 2020. Clinical significance of Kelch-like protein 11 antibodies. PMID: 31953318
  • Aboseif A et al. Neurol Neuroimmunol Neuroinflamm. 2024. Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis. PMID: 38484218

Need pricing information?

Get a quote

How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18