DIAGNOSTIC TEST 958

Lrp4 Antibodies

Diagnostic test for antibodies against Lrp4. For suspected Myasthenia gravis.

Indication

Suspicion of myasthenia gravis (MG)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

Negative

Result

Results are reported as negative, borderline or positive.

Interpretation

Lipoprotein receptor-related protein-4 (LRP4) is a membrane protein in the muscle endplate and forms together with muscle-specific kinase (MuSK) clusters of acetylcholine receptors (AChR).

Antibodies against LRP4 have been reported in 1-5% of patients with myasthenia gravis (MG) patients and can be seen without concomitant antibodies against AChR or MuSK (double negative MG).

When the result is borderline, testing a new sample after 6-12 months is recommended.

References

  • Zouvelou V et al. Neuromuscul Disord. 2013. Double seronegative myasthenia gravis with anti-LRP 4 antibodies. PMID: 23768983
  • Zisimopoulou P et al. J Autoimmun. 2014. A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis. PMID: 24373505
  • Berrih-Aknin S et al. J Autoimmun. 2014. Diagnostic and clinical classification of autoimmune myasthenia gravis. PMID: 24530233
  • Pevzner A et al. J Neurol. 2012. Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis. PMID: 21814823
  • Verschuuren J et al. Neurology. 2021 International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update. PMID: 33144515
  • Fichtner ML et al. Int Rev Neurobiol. 2025. Autoantibodies in myasthenia gravis. PMID: 40675742

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-10-09