DIAGNOSTIC TEST 015

MPO-ANCA (IgG)

Diagnostic test for antibodies against MPO. For suspicion of systemic vasculitis, especially with kidney involvement.

Indication

Suspicion of systemic vasculitis, especially with kidney involvement

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

FEIA (fluoroenzyme immunoassay), sensitive

Reference interval

< 3.5 IU/mL negative, 3.5-5.0 IU/mL borderline

Result

Results are reported as negative, borderline, or positive with a concentration (U/mL).

Interpretation

MPO-ANCA is a marker for the vasculitis diseases microscopic polyangiitis (MPA) and eosinophil granulomatosis with polyangiitis (EGPA), previously named Churg-Strauss syndrome. Antibody levels may decrease during remission, and an increasing level may suggest a relapse. MPO-ANCA may also occur in SLE, infections, and drug-induced conditions without relation to vasculitis.

References

  • Neumann I et al. Nephrol Dial Transplant. 2003. Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis. PMID: 12584274
  • Csernok E et al. Rheumatology (Oxford). 2002. A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis. PMID: 12422006
  • Basu N et al. Ann Rheum Dis. 2010. EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. PMID: 20448283.

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-10