DIAGNOSTIC TEST 872

Neurexin-3 Alpha Antibodies (IgG)

Diagnostic test for antibodies against Neurexin-3α. For suspicion of autoimmune encephalitis.

Indication

Suspicion of autoimmune encephalitis

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

Serum: <1:100 negative

CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

Autoantibodies against Neurexin-3 alpha have been reported in a few cases of autoimmune encephalitis. Typical clinical features are similar to NMDAR-encephalitis but with less prominent psychiatric symptoms.

References

  • Dalmau J et al. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
  • Pollak TA et al. Lancet Psychiatry 2020. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. PMID: 31669058
  • Ancona C et al. Front Pediatr. 2022. Autoimmune Encephalitis and Other Neurological Syndromes With Rare Neuronal Surface Antibodies in Children: A Systematic Literature Review. PMID: 35515348
  • Hansen N et al. Brain Sci. 2021. Mild Amnestic Cognitive Impairment and Depressive Symptoms in Autoimmune Encephalitis Associated with Serum Anti-Neurexin-3α Autoantibodies. PMID: 34064006

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-10-09