DIAGNOSTIC TEST 117

mGluR1 Antibodies (IgG)

Diagnostic test for antibodies against mGlur1. For suspicion of autoimmune encephalitis/autoimmune cerebellar ataxia.

Indication

Suspicion of autoimmune encephalitis or autoimmune cerebellar ataxia

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

<1:10 negative

Result

Results are reported as negative or positive with a titer.

Interpretation

Antibodies against mGluR1 have been described in (paraneoplastic) cerebellar ataxia, but other neurological symptoms may also occur. The antibodies are primarily associated with Hodgkin lymphoma.

References

  • Jarius S, Wildemann B. J Neuroinflammation. 2015. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. PMID: 26377085
  • Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
  • Chandler E et al. Child Neurol Open. 2022. A Novel Case of Idiopathic MGluR1 Encephalitis in a Pediatric Patient. PMID: 35497371
  • Vinke et al. Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2022 PMID: 35450924

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05