DIAGNOSTIC TEST 878

Sez6L2 Antibodies (IgG)

Diagnostic test for antibodies against SEZ6L2. For suspicion of autoimmune encephalitis.

Indication

Suspicion of autoimmune encephalitis

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

Serum: <1:10 negative

CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

Sez6L2 is highly expressed in the cerebellum and hippocampus. Antibodies against Sez6L2 have been reported in various neurological symptoms, usually cerebellar ataxia, dysarthria, and extrapyramidal symptoms, but cognitive impairment and epilepsy have also been described.

References

  • Kather A et al. Neurol Res Pract. 2022. Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature. PMID: 36310162
  • Landa J et al. Neurol Neuroimmunol Neuroinflamm. 2020. Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects. PMID: 33144342
  • Yaguchi H et al. J Neurol. 2018. Anti-Sez6l2 antibody detected in a patient with immune-mediated cerebellar ataxia inhibits complex formation of GluR1 and Sez6l2. PMID: 29423613
  • Mehdiyeva A et al. Neurol Neuroimmunol Neuroinflamm. 2022. SEZ6L2 Antibody-Associated Cerebellar Ataxia Responsive to Sequential Immunotherapy. PMID: 35031588

Need pricing information?

Get a quote

How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05