DIAGNOSTIC TEST 240

Streptolysin O Antibodies

Diagnostic test for antibodies against Streptolysin O. For suspicion of glomerulonephritis.

Indication

Suspicion of glomerulonephritis

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Agglutination

Reference interval

< 200 IU/mL negative

Result

Results are reported as negative or positive with a concentration.

Interpretation

Antibodies against streptococci can be detected after infection with beta-haemolytic streptococci group A and may be of some value in suspected rheumatic fever, acute post-streptococcal glomerulonephritis (APGN), or erythema nodosum. The antibody levels begin to rise about 1 week after the infection and reach their highest value after 3-5 weeks. Two samples at an interval of at least 4 weeks are recommended to determine the seroconversion. Positive anti-streptolysin-O is found in 80% of patients with rheumatic fever or acute post-streptococcal glomerulonephritis (APGN).

References

  • Blyth CC, Robertson PW. Pathology. 2006. Anti-streptococcal antibodies in the diagnosis of acute and post-streptococcal disease: streptokinase versus streptolysin O and deoxyribonuclease B. PMID: 16581656
  • Steer AC et al. Clin Vaccine Immunol. 2009. Normal ranges of streptococcal antibody titers are similar whether streptococci are endemic to the setting or not. PMID: 19052157
  • Rodriguez-Iturbe B, Musser JM. J Am Soc Nephrol. 2008. The current state of poststreptococcal glomerulonephritis. PMID: 18667731
  • Couser WG. Lancet. 1999. Glomerulonephritis. PMID: 10232333

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-10-09