DIAGNOSTISK ANALYS 005
CNTN1-antikroppar (IgG)
Diagnostisk analys för antikroppar mot CNTN1 (IgG) vid misstanke om inflammatorisk neuropati/autoimmun nodopati.
Indikation
Misstanke om inflammatorisk neuropati/autoimmun nodopati
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
<1:10 negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras.
Tolkning
Contactin-1 (CNTN1) är ett paranodalt protein. IgG antikroppar mot CNTN1 har beskrivits vid autoimmun nodopati.
Referenser
- Van den Bergh PYK et al. J Peripher Nerv Syst. 2021. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision. PMID: 34085743
- Dong M et al. Clin Neurol Neurosurg. 2022. Characterization of the patients with antibodies against nodal-paranodal junction proteins in chronic inflammatory demyelinating polyneuropathy. PMID: 36401951
- Querol LA et al. Neurotherapeutics. 2022. The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies. PMID: 35378684
- Cortese A et al. Neurol Neuroimmunol Neuroinflamm. 2019. Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype. PMID: 31753915
- Delmont E et al. Brain. 2017. Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. PMID: 28575198
- Appeltshauser L et al. Brain. 2023. Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage. PMID: 36346134
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Senast uppdaterad: 2026-09-30
