INDIVIDUAL TEST 141
cN-1A (Mup44) Antibodies (IgG)
Indication
Suspicion of sporadic inclusion body myositis (IBM)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
<1.0 negative
Result
Results are reported as negative or positive with a ratio.
Interpretation
IgG antibodies against cN-1A is a marker for inclusion body myositis (IBM) approximately 30% of patients are seropositive. Diagnostic specificity is indicated to be 93-95%. Low levels of antibodies can be detected in dermato-/polymyositis patients.
References
- Notarnicola A et al. J Autoimmun. 2024. Autoantibodies against a subunit of mitochondrial respiratory chain complex I in inclusion body myositis. PMID: 39561568
- Damoiseaux J et al. Autoimmun Rev. 2019. Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays. PMID: 30639643
Last updated: 2025-11-21
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ENSKILD ANALYS 141
cN-1A (Mup44)-antikroppar (IgG)
Indikation
Misstanke om sporadisk inklusionskroppsmyositis (IBM)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
ELISA
Referensintervall
< 1.0 negativt
Resultat
Resultat anges som negativt eller positivt med en kvot.
Tolkning
IgG-antikroppar mot cN-1A är markör för inklusionskroppsmyosit (IBM) och kan påvisas hos ca 30% av dessa patienter. Diagnostisk specificitet anges till 93–95%. Låga antikroppsnivåer kan även ses vid dermato-/polymyosit.
Referenser
- Notarnicola A et al. J Autoimmun. 2024. Autoantibodies against a subunit of mitochondrial respiratory chain complex I in inclusion body myositis. PMID: 39561568
- Damoiseaux J et al. Autoimmun Rev. 2019. Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays. PMID: 30639643
Senast uppdaterat: 2025-11-21