INDIVIDUAL TEST 146

Beta-2-Glycoprotein Antibodies (IgA)

IndicationIf suspicion of antiphospholipid syndrome (APS) remains despite negative results regarding the classical antiphospholipid associated antibodies (lupus anticoagulant (LA), IgG- and/or IgM-antibodies against beta2-Glycoprotein-1 and cardiolipin), IgA-antibodies against cardiolipin/ beta2-Glycoprotein-1 support the APS-diagnosis in isolated cases. In addition, antibodies against phosphatidylserine can be of value.MethodELISAAnswerThe result is given as negative or positive with a value (U/ml)InterpretationIgA-autoantibodies against ?2-Glycoprotein-1 are included in the SLICC-criteria for SLE and have been reported in “seronegative” antiphospholipid syndrome (APS), i.e. when the classical antiphospholipid antibodies (lupus anticoagulant, IgG- and/or IgM-antibodies against cardolipin and/or beta2-Glycoprotein-1) cannot be detected.