INDIVIDUAL TEST 146
Beta-2-Glycoprotein Antibodies (IgA)
Indication
Suspicion of antiphospholipid syndrome (APS)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
<20 U/mL negative
Result
Results are reported as negative or positive with a concentration (U/mL).
Interpretation
IgA-antibodies against Beta-2-Glycoprotein-1 are included in the SLICC-criteria for SLE and have been reported to occur in “seronegative” cases with antiphospholipid syndrome (APS), i.e. without detection of lupus anticoagulant, IgG and/or IgM antibodies against Cardiolipin and/or Beta-2-Glycoprotein-1.
References
- Frodlund M et al. Front Med (Lausanne). 2021. Longitudinal Analysis of Anti-cardiolipin and Anti-β2-glycoprotein-I Antibodies in Recent-Onset Systemic Lupus Erythematosus: A Prospective Study in Swedish Patients. PMID: 33732724
- Aringer M et al. Arthritis Rheumatol. 2019. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. PMID: 31385462
- Barbhaiya M et al. Ann Rheum Dis. 2023. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. PMID: 37640450
Last updated: 2025-12-01
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ENSKILD ANALYS 146
Beta-2-Glykoprotein 1-antikroppar (IgA)
Indikation
Misstanke om antifosfolipidsyndrom (APS)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
ELISA
Referensintervall
<20 U/mL negativt
Resultat
Resultatet anges som negativt eller positivt med koncentration (U/mL).
Tolkning
IgA-antikroppar mot beta-2-Glykoprotein-1 ingår i SLICC-criteria för SLE och har rapporterats förekomma i “seronegativa” fall med antifosfolipid syndrom (APS), dvs utan att lupus antikoagulans, IgG- och/eller IgM-antikroppar mot kardolipin och/eller beta-2-Glykoprotein-1 kan påvisas.
Referenser
- Frodlund M et al. Front Med (Lausanne). 2021. Longitudinal Analysis of Anti-cardiolipin and Anti-β2-glycoprotein-I Antibodies in Recent-Onset Systemic Lupus Erythematosus: A Prospective Study in Swedish Patients. PMID: 33732724
- Aringer M et al. Arthritis Rheumatol. 2019. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. PMID: 31385462
- Barbhaiya M et al. Ann Rheum Dis. 2023. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. PMID: 37640450
Senast uppdaterat: 2025-12-01