INDIVIDUAL TEST 205
Envoplakin Antibodies (IgG)
Indication
Suspicion of paraneoplastic pemphigus
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
<1.0 negative
Result
Results are reported as negative or positive with a ratio.
Interpretation
Anti-envoplakin (IgG) antibodies occur in PNP (paraneoplastic pemphigus) association with lymphoproliferative diseases like non-Hodgkins’s lymphoma and CLL (chronic lymphocytic leukemia). Antibody concentration correlates with disease activity and may be used to monitor treatment efficacy.
References
- Baum S et al. Autoimmun Rev. 2014. Diagnosis and classification of autoimmune blistering diseases. PMID: 24434358
- Garbanzos CCT et al. J Cutan Pathol. 2025. Clinical, Serologic, and Histopathologic Features of Patients With Pemphigus With Either Positive or Negative IgG4 Intercellular Deposition by Direct Immunofluorescence (DIF): A Retrospective Case-Control Study of 55 DIF Biopsy Specimens. PMID: 40555471
- van Beek N et al. Front Immunol. 2024. State-of-the-art diagnosis of autoimmune blistering diseases. PMID: 38903493
Last updated: 2025-11-21
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ENSKILD ANALYS 205
Envoplakin-antikroppar (IgG)
Indikation
Misstanke om paraneoplastisk pemfigus
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
ELISA
Referensintervall
<1.0 negativt
Resultat
Resultat anges som negativt eller positivt med kvot.
Tolkning
Anti-envoplakin (IgG) antikroppar förekommer vid PNP (paraneoplastisk pemfigus) med association till lymfoproliferativa sjukdomar som non-Hodgkins lymfom och KLL (kronisk lymfatisk leukemi). Antikroppskoncentrationen korrelerar med sjukdomsaktivitet och kan användas för att följa behandlingseffekt.
Referenser
- Baum S et al. Autoimmun Rev. 2014. Diagnosis and classification of autoimmune blistering diseases. PMID: 24434358
- Garbanzos CCT et al. J Cutan Pathol. 2025. Clinical, Serologic, and Histopathologic Features of Patients With Pemphigus With Either Positive or Negative IgG4 Intercellular Deposition by Direct Immunofluorescence (DIF): A Retrospective Case-Control Study of 55 DIF Biopsy Specimens. PMID: 40555471
- van Beek N et al. Front Immunol. 2024. State-of-the-art diagnosis of autoimmune blistering diseases. PMID: 38903493
Senast uppdaterat: 2025-11-21