INDIVIDUAL TEST 957
KLHL11 Antibodies (IgG)
Indication
Suspicion of paraneoplastic cerebellar encephalitis
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
Serum
- <1/1000 negative
CSF
- <1/100 negative
Result
Results are reported as negative, borderline, or positive.
Interpretation
Kelch-like protein 11 (KLHL11) is a subunit of the E3 ubiquitin ligase complex. IgG antibodies against KLHL11 have been reported in paraneoplastic cerebellar encephalitis.
References
- Maudes E et al. Neurol Neuroimmunol Neuroinflamm. 2020. Clinical significance of Kelch-like protein 11 antibodies. PMID: 31953318
- Aboseif A et al. Neurol Neuroimmunol Neuroinflamm. 2024. Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis. PMID: 38484218
Last updated: 2024-09-10
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ENSKILD ANALYS 957
KLHL11-antikroppar (IgG)
Indikation
Misstanke om paraneoplastisk cerebellär encefalit
Provmaterial
Serum
- Minim. volym: 0,5 mL
CSF
- Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)Referensintervall
Serum
- <1/1000 negativt
CSF
- <1/100 negativt
Resultat
Resultat anges som negativt, gränsvärde eller positivt.
Tolkning
Kelch-like protein 11 (KLHL11) förekommer som en subenhet i E3 ubiquitin ligas komplexet. IgG antikroppar mot KLHL11 har rapporterats vid paraneoplastisk cerebellär encefalit.
Referenser
- Maudes E et al. Neurol Neuroimmunol Neuroinflamm. 2020. Clinical significance of Kelch-like protein 11 antibodies. PMID: 31953318
- Aboseif A et al. Neurol Neuroimmunol Neuroinflamm. 2024. Immune Checkpoint Inhibitor-Associated Kelch-Like Protein-11 IgG Brainstem Encephalitis. PMID: 38484218
Senast uppdaterat: 2024-09-10