DIAGNOSTIC TEST 959

Ganglionic AChR Antibodies

Diagnostic test for antibodies against Ganglionic AChR2. For suspected autoimmune autonomic neuropathies.

Indication

Suspicion of autoimmune autonomic neuropathies

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Radioimmunoprecipitation (RIP)

Reference interval

<10 pmol/L negative

10-15 pmol/L borderline

Result

The result is reported as negative, borderline or positive with a value.

Interpretation

Antibodies against nicotinic ganglionic acetylcholine receptors (g-AChR) can cause autoimmune autonomic ganglionopathy (AAG), a rare autoimmune disease affecting the sympathetic and parasympathetic ganglia leading to dysautonomia. The alpha-3 subunit is considered to be the main target antigen. Antibody titers correlates with the severity of symptoms.

References

  • Koike H et al. J Neurol Neurosurg Psychiatry. 2013. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. PMID: 22906617
  • Koay S et al. Ann Neurol. 2021. Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy. PMID: 33438240
  • Pechlivanidou M et al. Pharmacol Res. 2023. Autoimmunity to neuronal nicotinic acetylcholine receptors. PMID: 37164280

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-09-21