INDIVIDUAL TEST 959
Ganglionic AChR Antibodies
Indication
Suspected autoimmune autonomic neuropathies
Method
The test is performed in serum with Radioimmunoprecipitation (RIA)
Result
The result is reported as negative, borderline or positive with a value.
Reference interval:
<10 pmol/L negative
10-15 pmol/L borderline
Interpretation
Antibodies against nicotinic ganglionic acetylcholine receptors (g-AChR) can cause autoimmune autonomic ganglionopathy (AAG), a rare autoimmune disease affecting the sympathetic and parasympathetic ganglia leading to dysautonomia. The alpha-3 subunit is considered to be the main target antigen. Antibody titers correlates with the severity of symptoms.
References
Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000 Sep 21;343(12):847-55.PMID: 10995864
Koike H, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):98-106. PMID: 22906617
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ENSKILD ANALYS 959
Ganglionära AChR-antikroppar
Indikation
Misstanke om autoimmuna autonomiska neuropatier
Metod
Analysen utförs i serum med Radioimmunoprecipitation (RIA)
Resultat
Resultatet anges som negativt, gränsvärde eller positivt med värde.
Referensintervall:
<10 pmol/L negativt
10-15 pmol/L gränsvärde
Tolkning
Antikroppar mot nikotinerg ganglionär acetylkolinreceptor (g-AChR) kan orsaka autoimmun autonom gangliopati (AAG) som är en mycket ovanlig autoimmun sjukdom som drabbar sympatiska och parasympatiska ganglier med autonom dysfunktion som följd. Alfa-3-subenheten anses vara det viktigaste mål antigenet. Antikroppstitrarna korrelerar till graden av symptom.
Referenser
Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000 Sep 21;343(12):847-55.PMID: 10995864
Koike H, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):98-106. PMID: 22906617