Vial

INDIVIDUAL TEST 959

Ganglionic AChR Antibodies

Indication

Suspected autoimmune autonomic neuropathies

Method

The test is performed in serum with Radioimmunoprecipitation (RIA)

Result

The result is reported as negative, borderline or positive with a value.

Reference interval:
<10 pmol/L negative
10-15 pmol/L borderline

Interpretation

Antibodies against nicotinic ganglionic acetylcholine receptors (g-AChR) can cause autoimmune autonomic ganglionopathy (AAG), a rare autoimmune disease affecting the sympathetic and parasympathetic ganglia leading to dysautonomia. The alpha-3 subunit is considered to be the main target antigen. Antibody titers correlates with the severity of symptoms.

References

  • Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000 Sep 21;343(12):847-55.PMID: 10995864
  • Koike H, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):98-106. PMID: 22906617

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Vial

ENSKILD ANALYS 959

Ganglionära AChR-antikroppar

Indikation

Misstanke om autoimmuna autonomiska neuropatier

Metod

Analysen utförs i serum med Radioimmunoprecipitation (RIA)

Resultat

Resultatet anges som negativt, gränsvärde eller positivt med värde.

Referensintervall:
<10 pmol/L negativt
10-15 pmol/L gränsvärde

Tolkning

Antikroppar mot nikotinerg ganglionär acetylkolinreceptor (g-AChR) kan orsaka autoimmun autonom gangliopati (AAG) som är en mycket ovanlig autoimmun sjukdom som drabbar sympatiska och parasympatiska ganglier med autonom dysfunktion som följd. Alfa-3-subenheten anses vara det viktigaste mål antigenet. Antikroppstitrarna korrelerar till graden av symptom.

Referenser

  • Vernino S, Low PA, Fealey RD, Stewart JD, Farrugia G, Lennon VA. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N Engl J Med. 2000 Sep 21;343(12):847-55.PMID: 10995864
  • Koike H, Watanabe H, Sobue G. The spectrum of immune-mediated autonomic neuropathies: insights from the clinicopathological features. J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):98-106. PMID: 22906617

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