DIAGNOSTIC TEST 146

Beta-2-Glycoprotein Antibodies (IgA)

Diagnostic test for antibodies against Beta-2-Glycoprotein 1 (IgA). For suspicion of antiphospholipid syndrome (APS).

Indication

Suspicion of antiphospholipid syndrome (APS)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

ELISA

Reference interval

<20 U/mL negative

Result

Results are reported as negative or positive with a concentration (U/mL).

Interpretation

IgA-antibodies against Beta-2-Glycoprotein-1 are included in the SLICC-criteria for SLE and have been reported to occur in “seronegative” cases with antiphospholipid syndrome (APS), i.e. without detection of lupus anticoagulant, IgG and/or IgM antibodies against Cardiolipin and/or Beta-2-Glycoprotein-1.

References

  • Frodlund M et al. Front Med (Lausanne). 2021. Longitudinal Analysis of Anti-cardiolipin and Anti-β2-glycoprotein-I Antibodies in Recent-Onset Systemic Lupus Erythematosus: A Prospective Study in Swedish Patients. PMID: 33732724
  • Aringer M et al. Arthritis Rheumatol. 2019. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. PMID: 31385462
  • Barbhaiya M et al. Ann Rheum Dis. 2023. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. PMID: 37640450

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-01