DIAGNOSTIC TEST 926

C1 INH Function

Diagnostic test for C1 INH function. For investigation of angioedema.

Indication

Suspicion of angioedema

Sample material

EDTA-plasma

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: frozen
  • International: frozen

Method

Spectrophotometry

Reference interval

72-129%

Result

The result is reported as normal or low as a percentage of normal human serum.

Interpretation

Results below the lower reference limit may indicate hereditary angioedema (HAE) type 1 or consumption of C1-inhibitor (can be seen in some malignancies). The result should primarily be verified with a new sample as well as to include analysis of the concentrations of C1-inhibitor and C4.

References

  • Li HH et al. Allergy Asthma Clin Immunol. 2019. Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study. PMID: 31485239
  • Maurer M et al. World Allergy Organ J. 2022. The international WAO/EAACI guideline for the management of hereditary angioedema - The 2021 revision and update. PMID: 35497649

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    EDTA Plasma: At least 0.5 mL blood plasma (EDTA tubes).

  3. Send samples and request form

    Within Sweden
    Send samples frozen to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples frozen to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05