DIAGNOSTIC TEST 141

cN-1A (Mup44) Antibodies (IgG)

Diagnostic test for antibodies against cN-1A. For suspicion of inclusion body myositis (IBM).

Indication

Suspicion of sporadic inclusion body myositis (IBM)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

ELISA

Reference interval

<1.0 negative

Result

Results are reported as negative or positive with a ratio.

Interpretation

IgG antibodies against cN-1A is a marker for inclusion body myositis (IBM) approximately 30% of patients are seropositive. Diagnostic specificity is indicated to be 93-95%. Low levels of antibodies can be detected in dermato-/polymyositis patients.

References

  • Notarnicola A et al. J Autoimmun. 2024. Autoantibodies against a subunit of mitochondrial respiratory chain complex I in inclusion body myositis. PMID: 39561568
  • Damoiseaux J et al. Autoimmun Rev. 2019. Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays. PMID: 30639643

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-21