DIAGNOSTIC TEST 005
CNTN1 Antibodies (IgG)
Diagnostic test for antibodies against CNTN1 (IgG). For suspicion of inflammatory neuropathy/autoimmune nodopathy.
Indication
Suspicion of inflammatory neuropathy/autoimmune nodopathy
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
<1:10 negative
Result
Results are reported as negative or positive. A positive result is followed by a titer.
Interpretation
Contactin-1 (CNTN1) is a paranodal protein. IgG antibodies against CNTN1 have been reported in autoimmune nodopathy.
References
- Van den Bergh PYK et al. J Peripher Nerv Syst. 2021. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision. PMID: 34085743
- Dong M et al. Clin Neurol Neurosurg. 2022. Characterization of the patients with antibodies against nodal-paranodal junction proteins in chronic inflammatory demyelinating polyneuropathy. PMID: 36401951
- Querol LA et al. Neurotherapeutics. 2022. The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies. PMID: 35378684
- Cortese A et al. Neurol Neuroimmunol Neuroinflamm. 2019. Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype. PMID: 31753915
- Delmont E et al. Brain. 2017. Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. PMID: 28575198
- Appeltshauser L et al. Brain. 2023. Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage. PMID: 36346134
Included in these panels
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How to order
This test is only available as part of a test panel.
Last updated: 2026-09-30
