DIAGNOSTIC TEST PANEL 589

Primary Membranous Nephropathy (PMN) – Extended Analysis

Diagnostic test panel for antibodies against NELL1, CNTN1 and CASPR1. For suspicion of primary membranous nephropathy (PMN).

Indication

For suspicion of primary membranous nephropathy (PMN)

Sample material

Serum

  • Minim. volume: 1 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Clinical background

Primary membranous nephropathy (PMN) is caused by autoantibodies against renal glomeruli. Antibodies against PLA2R are the most common, but antibodies against THSD7A, NELL1, and CNTN1 occur in 2–15% of cases.

NELL1 (Neural Epidermal Growth Factor-Like 1) antibodies are detected in 5–10% of patients with PMN. NELL1 antibodies may occur secondary to other autoimmune diseases and following treatment with thiol-containing drugs. Malignancy has been reported in 15–33% of patients with NELL1 antibodies.

The antigens CNTN1 (Contactin-1) and CASPR1 (Contactin-associated protein 1) are expressed in both renal glomerular podocytes and peripheral nerves. Antibodies against CNTN1/CASPR1 are associated with a distinct autoimmune syndrome characterized by the co-occurrence of PMN and chronic inflammatory demyelinating polyneuropathy (CIDP).

Tests included in panel

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How to order

This test panel is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 1 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-09-30