DIAGNOSTIC TEST 852

IgLON5 Antibodies  (IgG)

Diagnostic test for antibodies against IgLON5. For suspicion of autoimmune encephalitis.

Indication

Suspicion of autoimmune encephalitis

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

Serum: <1:10 negative

CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

Anti-IgLON5 disease is a chronic condition characterized by parasomnia with obstructive sleep apnea. Bulbar symptoms, gait abnormalities and cognitive impairment have also been described.

References

  • Sabater L et al. Lancet Neurol. 2014. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. PMID: 24703753
  • Leypoldt F et al. Ann N Y Acad Sci. 2014. Autoimmune encephalopathies. Oct 14. PMID: 25315420
  • Farina A et al. Neurol Neuroimmunol Neuroinflamm. 2025. Serum Neurofilament Light Chain Correlates With Clinical Severity and Predicts Mortality in Anti-IgLON5 Disease. PMID: 41061184
  • Grüter T et al. JAMA Neurol. 2025. Early Treatment With Intravenous Immunoglobulins and Outcomes of Patients With Anti-IgLON5 Disease. PMID: 40758377
  • Campetella L et al. J Neurol. 2025. Neurodegeneration and the immune system: lessons from autoimmune encephalitis. PMID: 40274643
  • Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2025. Anti-IgLON5 Disease 10 Years Later: What We Know and What We Do Not Know. PMID: 39705634

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-25