DIAGNOSTIC TEST 110

Insulin Antibodies

Diagnostic test for antibodies against insulin. For suspicion of type 1 diabetes (T1D).

Indication

Suspicion of type 1 diabetes (T1D)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

CLIA

Reference interval

COI < 0.9 negative, COI 0.9-1.1 borderline

Result

Results are reported as negative, borderline, or positive with a Cut-Off Index (COI).

Interpretation

IgG-antibodies against insulin can be found in type 1 diabetes (T1D) but the prevalence is lower compared to antibodies against GAD-65 or IA-2. During treatment with insulin the antibodies can be absorbed resulting in false low values. Sampling for detection of antibodies against insulin shall therefore be performed when the blood level of insulin is as low as possible.

References

  • Toft-Hansen H et al. Int J Mol Sci. 2025 Characterization of Anti-Insulin Antibodies in Type 1 and Type 2 Diabetes Mellitus: Clinical Relevance. PMID: 40004193

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-19