DIAGNOSTIC TEST 084

Mitochondrial Antibodies (AMA)

Diagnostic test for antibodies against mitochondria (AMA). For suspicion of primary biliary cholangitis (PBC) or autoimmune hepatitis.

Indication

Suspicion of Suspicion of primary biliary cholangitis (PBC) or autoimmune hepatitis

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Indirect immunofluorescence (IIF)

Reference interval

<1:100 negative

Result

Results are reported as negative or positive with a titer.

Interpretation

AMA type M2 is a strong marker for established or future development of primary biliary cholangitis (PBC) and occurs in about 90% of the cases. PBC is a chronic autoimmune disease that affects the intrahepatic bile ducts resulting in cholestasis.

References

  • European Association for the Study of the Liver. J Hepatol. 2025. EASL Clinical Practice Guidelines on the management of autoimmune hepatitis. PMID: 40348684
  • Marschall HU et al. Sci Rep. 2019. Incidence, prevalence, and outcome of primary biliary cholangitis in a nationwide Swedish population-based cohort. PMID: 31395896

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-19