DIAGNOSTIC TEST PANEL 515
Autoimmune Liver Disease
Diagnostic test panel for LKM-1, LC-1, AMA-M2, M2-3E (BPO), Sp100, PML, gp210, SLA/LP, Ro-52, and ANA (HEp-2) and antibodies against smooth muscle (SMA) and mitochondria (AMA). For suspicion of autoimmune liver disease.
This panel includes samples for basic examination. See also Autoimmune liver diseases screen (018).
Indication
Suspicion of autoimmune liver disease.
Clinical background
Different types of autoimmune hepatitis can affect both sexes of all ages. The clinical picture may vary from a mild or even subclinical disease to acute relapses of liver failure. The onset of the disease may also be cryptogenic cholangitis. In autoimmune hepatitis type 1, 70% of the patients have antibodies against smooth muscle, 10% have antibodies against SLA/LP. Isolated occurrence of anti-SLA/LP has been reported.
ANA is often positive in autoimmune hepatitis type 1 with varying patterns. Autoimmune hepatitis type 2 is not common in northern Europe and mainly affects young women. The disease is defined by the presence of antibodies against LKM-1 or LC-1. Most patients with primary biliary cholangitis have antibodies against mitochondria (AMA and mitochondria type M2).
There is no specific serological marker for primary sclerosing cholangitis, even if these patients in 20-30% of the cases show a positive ANA with a pattern of nuclear dots. Some patients have atypical ANCA with immunofluorescence investigation.
Tests included in panel
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How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 1 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Samples can be sent at room temperature to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
