DIAGNOSTIC TEST 247

PLA2R Antibodies ELISA (IgG)

Diagnostic test for antibodies against PLA2R. For suspicion of primary membranous nephropathy (PMN).

Indication

Suspicion of primary membranous nephropathy (PMN)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

ELISA

Reference interval

< 14 RU/mL negative, 14-19 RU/mL borderline

Result

Results are reported as negative, borderline or positive with a concentration.

Interpretation

Antibodies against PLA2R is a strong marker for primary membrane nephropathy (PMN) and occur in serum of 75% of these patients. The levels are usually higher than borderline. The antibodies lead to complement-activating immune complexes on the basal membrane in glomeruli causing tissue damage and proteinuria. Higher levels of antibodies are associated with increased disease activity and monitoring the antibodies levels can be used to follow treatment effect.

References

  • Ronco P, Debiec H. Lancet. 2015. Pathophysiological advances in membranous nephropathy: time for a shift in patient's care. PMID: 26090644
  • Larsen CP et al. Mod Pathol. 2016. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. PMID: 26847174
  • Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. Kidney Int. 2024. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. PMID: 38490803
  • Rovin BH et al. Kidney Int. 2021. Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases. PMID: 34556300

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-10