DIAGNOSTIC TEST 805

Plexin D1 Antibodies (IgG)

Diagnostic test for antibodies against Plexin D1. For suspicion of small fiber neuropathy.

Indication

Suspicion of small fiber neuropathy (SFN)

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Western Blot

Reference interval

Negative

Result

Results are reported as negative, borderline, or positive.

Interpretation

Antibodies against Plexin D1 can be detected in polyneuropathy patients with sensory polyneuropathy, which is often characterized as burning pain and thermal hyperalgesia.

References

  • Fujii T et al. Ann Neurol. 2018. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. PMID: 30014510
  • Fujii T et al. Neurol Neuroimmunol Neuroinflamm. 2020. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. PMID: 32587101
  • Zeidman LA. Neurol Clin. 2021. Advances in the Management of Small Fiber Neuropathy. PMID: 33223078
  • Morelli L et al. Rev Neurosci. 2024. The role of antibodies in small fiber neuropathy: a review of currently available evidence. PMID: 38865989

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05