DIAGNOSTIC TEST 710

PM/Scl (100kD) Antibodies

Diagnostic test for antibodies against PM/Scl. For suspicion of polymyositis/scleroderma overlap syndrome, scleroderma, and unclear myositis.

Indication

Suspicion of polymyositis/scleroderma overlap syndrome, scleroderma, unclear myositis

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Fluorescence enzyme immunoassay (FEIA)

Reference interval

< 7 U/mL negative, 7-10 U/mL borderline

Result

Results are reported as negative borderline, or positive with a concentration.

Interpretation

Antibodies against the PM-Scl complex are associated with myositis that clinically overlap with other rheumatic systemic diseases and are often associated with Raynaud's phenomenon, arthritis, muscle involvement and effects on the skin and lungs. Usually, positive ANA with a nucleolar pattern is also seen. The antibodies are usually directed against the subunits 75 kD and 100 kD.

References

  • Satoh M. et al. Clinic Rev Allerg Immunol. 2017. A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy. PMID: 26424665
  • Lundberg IE et al. Ann Rheum Dis. 2017. European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. PMID: 29079590
  • Allenbach Y et al. Neuromuscul Disord. 2018. 224th ENMC International Workshop: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14–16 October 2016. PMID: 29221629
  • Lundberg IE et al. Nat Rev Dis Primers. 2021. Idiopathic inflammatory myopathies. PMID: 34857780

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-10