DIAGNOSTIC TEST PANEL 527

Systemic Sclerosis/Scleroderma – Extended Analysis

Diagnostic test panel for antibodies against RNA polymerase, fibrillarin, PM/Scl, and Th/To. For suspicion of Systemic Sclerosis/Scleroderma.

Indication

In-depth analysis is ordered when diagnosis has been established or if there is a strong suspicion of scleroderma/systemic sclerosis and when it is desired to differentiate between sub-entities. As shown in the investigation algorithm below, the analysis may be extended with a determination of antibodies against PM-Scl (p100), Th/To, RNA polymerase, and Fibrillarin.

Clinical background

It is a disease with an unclear etiology, which affects many organ systems, mainly the skin and the blood vessels. Still, the lungs and the gastrointestinal tract may also be affected. Kidney, heart, and muscle symptoms are less common. The most common clinical characteristics are dermatofibrosis of varying intensity and extent and circulation disorders in fingers and toes (Raynaud’s phenomenon). The disease is usually divided into different forms, such as:

  • Limited form (usually in the face and distally toward the elbow and knee) fits in with CREST syndrome.
  • Diffuse forms of skin symptoms, proximally to the elbow and on the body.
  • Overlap syndrome.
  • Serological investigation

Tests included in panel

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How to order

This test panel is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Samples can be sent at room temperature to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18