DIAGNOSTIC TEST 082

Smooth Muscle Antibodies (SMA)

Diagnostic test for antibodies against smooth muscle (SMA). For suspicion of autoimmune hepatitis (AIH) type 1.

Indication

Suspicion of autoimmune hepatitis (AIH) type 1

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Indirect immunofluorescence (IIF)

Reference interval

<1:100 negative

Result

Results are reported as negative or positive with a titer.

Interpretation

Smooth muscle antibodies (SMA) is a marker for autoimmune hepatitis (AIH) type 1 and a positive reaction is often observed in patients at the time of diagnosis. The antibody levels decrease during immunosuppressive treatment and a low positive SMA level can also be found in about 5% of healthy individuals.

References

  • European Association for the Study of the Liver. J Hepatol. 2025. EASL Clinical Practice Guidelines on the management of autoimmune hepatitis. PMID: 40348684

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-11-19