DIAGNOSTIC TEST 028

SSB/La Antibodies

Diagnostic test for antibodies against SSB. For suspicion of Sjogren's syndrome and systemic lupus erythematosus.

Indication

Suspicion of Sjogren's syndrome and systemic lupus erythematosus

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Method

Immunoblot

Reference interval

  • ≤10 negative

Result

Results are reported as negative or positive with an intensity value. Positive results are confirmed with ELISA.

Interpretation

Anti-SSB (La) antibodies occur almost always in conjunction with anti-SSA and are seen above all in primary Sjogren's syndrome and systemic lupus erythematosus. Antibodies against SSB (La) are also associated with small fiber neuropathy. The clinical relevance of isolated anti-SSB antibodies is unclear.

References

  • Tomer Y et al. Int Arch Allergy Immunol. 1993. Pathogenic significance and diagnostic value of lupus autoantibodies. PMID: 8481649
  • von Mühlen CA, Tan EM. Semin Arthritis Rheum. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. PMID: 7604300
  • Van Duijnhoven HL et al. Clin Biochem. 1999. A comparison of ELISA assays as routine diagnostic test for detection of autoantibodies against extractable nuclear antigens. PMID: 10383077
  • Hiepe F et al. Int Arch Allergy Immunol. 2000. Antinuclear antibody- and extractable nuclear antigen-related diseases. PMID: 11014966
  • Mahler M et al. Clin Immunol. 2003. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. PMID: 12763475
  • Hennes EM et al. Hepatology. 2008. Simplified criteria for the diagnosis of autoimmune hepatitis. PMID: 18537184
  • Damoiseaux J et al. Ann Rheum Dis. 2019. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. PMID: 30862649

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Samples can be sent at room temperature to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18