DIAGNOSTIC TEST 028

SSB/La Antibodies

Diagnostic test for antibodies against SSB. For suspicion of Sjögren's syndrome and systemic lupus erythematosus.

Indication

Suspicion of Sjögren's syndrome and systemic lupus erythematosus

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Method

Immunoblot

Reference interval

<11 negative

Result

Results are reported as negative or positive with reaction intensity. Positive results are confirmed with ELISA.

Interpretation

Antibodies against SSB (La) occur predominantly in combination with anti-SSA and are seen mainly in primary Sjögren's syndrome and systemic lupus erythematosus. The clinical relevance of isolated anti-SSB antibodies is unclear.

References

  • Hennes EM et al. Hepatology. 2008. Simplified criteria for the diagnosis of autoimmune hepatitis. PMID: 18537184
  • Damoiseaux J et al. Ann Rheum Dis. 2019. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. PMID: 30862649
  • Bonroy C et al. European Federation of Laboratory Medicine (EFLM) Working Group “Autoimmunity Testing,” the European Autoimmune Standardization Initiative (EASI) and International Consensus on Antinuclear Antibody Patterns (ICAP). Clin Chem Lab Med 2023 Detection of antinuclear antibodies: recommendations from EFLM, EASI and ICAP. PMID: 36989417
  • Vroemen WHM et al. J Transl Autoimmun 2025. An international multicenter retrospective analysis of repeated anti-ENA testing in ANA-associated rheumatic diseases, a data-driven proposal to increase testing efficacy. PMID: 40678815

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-08-13