INDIVIDUAL TEST 710
PM/Scl (100kD) Antibodies
Indication
Suspicion of polymyositis/scleroderma overlap syndrome, scleroderma, unclear myositis
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: room temperature
Method
Fluorescence enzyme immunoassay (FEIA)
Reference interval
< 7 U/mL negative, 7-10 U/mL borderline
Result
Results are reported as negative borderline, or positive with a concentration.
Interpretation
Antibodies against the PM-Scl complex are associated with myositis that clinically overlap with other rheumatic systemic diseases and are often associated with Raynaud's phenomenon, arthritis, muscle involvement and effects on the skin and lungs. Usually, positive ANA with a nucleolar pattern is also seen. The antibodies are usually directed against the subunits 75 kD and 100 kD.
References
- Satoh M. et al. Clinic Rev Allerg Immunol. 2017. A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy. PMID: 26424665
- Lundberg IE et al. Ann Rheum Dis. 2017. European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. PMID: 29079590
- Allenbach Y et al. Neuromuscul Disord. 2018. 224th ENMC International Workshop: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14–16 October 2016. PMID: 29221629
- Lundberg IE et al. Nat Rev Dis Primers. 2021. Idiopathic inflammatory myopathies. PMID: 34857780
Last updated: 2025-10-09
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ENSKILD ANALYS 710
PM/Scl (100kD)-antikroppar
Indikation
Misstanke om polymyosit/sklerodermi overlap syndrom, sklerodermi, oklar myosit
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: rumstemperatur
Metod
Fluorescensimmunanalys (FEIA)
Referensintervall
<7 U/mL negativt, 7-10 U/mL gränsvärde
Resultat
Resultat anges som negativt, gränsvärde eller positivt med koncentration.
Tolkning
Antikroppar mot PM-Scl-komplexet är associerade med myosit som kliniskt överlappar med andra reumatiska systemsjukdomar och ofta associerade med Raynaud-fenomen, artrit, muskelpåverkan och påverkan på hud och lungor. Vanligtvis ses även positiv ANA med nukleolärt mönster. Antikropparna är vanligen riktade mot subenheterna 75 kD och 100 kD.
Referenser
- Satoh M. et al. Clinic Rev Allerg Immunol. 2017. A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy. PMID: 26424665
- Lundberg IE et al. Ann Rheum Dis. 2017. European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. PMID: 29079590
- Allenbach Y et al. Neuromuscul Disord. 2018. 224th ENMC International Workshop: Clinico-sero-pathological classification of immune-mediated necrotizing myopathies Zandvoort, The Netherlands, 14–16 October 2016. PMID: 29221629
- Lundberg IE et al. Nat Rev Dis Primers. 2021. Idiopathic inflammatory myopathies. PMID: 34857780
Senast uppdaterat: 2025-10-09