INDIVIDUAL TEST 710
PM/Scl (100kD) Antibodies
Indication
Suspicion of polymyositis/scleroderma overlap syndrome, scleroderma, unclear myositis.
Method
Fluorescence enzyme immunoassay (FEIA).
Result
The result is given as negative, borderline, or positive.InterpretationThe PM/Scl antigen is found in the exosome, a complex consisting of 11-16 proteins in the granular part of the nucleoli and the nucleoplasma. The proteins act as exoribonucleases during the RNA processing.
Antibodies against the PM-Scl complex are associated with polymyositic/systemic sclerosis overlap syndrome. The antibodies are usually associated with positive ANA with nucleolar patterns. Anti-PM-Scl may be directed to different subunits in the PM-Scl complex, usually the 75 kD and 100 kD subunits. Anti-PM-Scl is often associated with Raynaud's phenomenon, arthritis, muscle aches, and effects on the skin and lungs.
Last updated: 2024-06-17
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ENSKILD ANALYS 710
PM/Scl (100kD)-antikroppar
Indikation
Misstanke om polymyosit/sklerodermi overlap syndrom, sklerodermi, oklar myosit.
Metod
Fluorescensimmunanalys (FEIA)
Resultat
Resultatet anges som negativt, gränsvärde eller positivt.TolkningPM/Scl antigenet finns i exosomen, ett komplex bestående av 11-16 proteiner som finns i den granulära delen av nukleoli och i nukleoplasman. Proteinerna fungerar som exoribonukleas under RNA processningen.
Antikroppar mot PM-Scl-komplexet är associerade med polymyosit/systemisk skleros överlappningssyndrom. Antikropparna är vanligtvis associerade med positiv ANA med nukleolärt mönster. Anti-PM-Scl kan vara riktade mot olika subenheter i PM-Scl-komplexet, vanligen subenheterna 75 kD och 100 kD. Anti-PM-Scl är ofta associerade med Raynaud-fenomen, artrit, muskelpåverkan och påverkan på hud och lungor.
Senast uppdaterat: 2024-06-17