INDIVIDUAL TEST 991
pTau
Indication
Suspicion of Alzheimer's disease or memory investigation
Sample material
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: frozen
- International: frozen
Method
Chemiluminescence enzyme immunoassay (CELEIA)
Reference interval
< 50 ng/L ( ≥50 years)
Result
Results are reported as a concentration (ng/L).
Interpretation
Tau is a structural protein that mostly occurs in the cortical, unmyelinated axons. Hyperphosphorylation of Tau is considered a step in the formation of Tau fibrils. Increased level of p-Tau in CSF can be seen in early stages of Alzheimer’s disease and is connected to the degree of pathological changes. The levels of p-Tau increase with the progression and severity of the disease.
References
- Jack CR Jr et al. Alzheimers Dement. 2024. Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup. PMID: 38934362
- Woyk K et al. J Alzheimers Dis Rep. 2025. The relationship of 18F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits. PMID: 40290782
Last updated: 2025-12-05
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ENSKILD ANALYS 991
pTau
Indikation
Misstanke om Alzheimers sjukdom och vid minnesutredning
Provmaterial
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: fryst
- Internationellt: fryst
Metod
Kemiluminescens enzymimmunanalys (CELEIA)
Referensintervall
< 50 ng/L (≥50 år)
Resultat
Resultat anges som koncentration (ng/L).
Tolkning
Tau är ett strukturellt protein som mest förekommer i kortikala, omyeliniserade axoner. Hyperfosforylering av Tau anses vara ett steg i formering av Tau-fibriller. Förhöjd nivå av p-Tau i likvor kan ses i tidigt i förloppet av Alzheimers sjukdom och är kopplad till graden av patologiska förändringar. Nivåerna av p-Tau ökar med sjukdomsprogress och svårighetsgrad.
Referenser
- Jack CR Jr et al. Alzheimers Dement. 2024. Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup. PMID: 38934362
- Woyk K et al. J Alzheimers Dis Rep. 2025. The relationship of 18F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits. PMID: 40290782
Senast uppdaterat: 2025-12-05