DIAGNOSTIC TEST PANEL 567
Alzheimer's Disease Biomarkers
Diagnostic test panel for Tau, pTau, and Ratio Aβ42/40. For suspicion of Alzheimer's Disease.
Indication
Suspicion of Alzheimer's Disease.
Sample material
CSF
- Minim. volume: 1.5 mL (0.5 mL x 3 tubes)
Transport
Within Sweden
- frozen
International
- frozen
Clinical background
Alzheimer's disease (AD) is characterized by amyloid-beta-(amyloid-β) plaques in the brain with aggregation of phosphorylated tau (p-tau) fibrils in neurons. These changes cause tissue damage and neuron loss. The pathophysiological mechanisms that lead to the neuronal damage are initiated many years before cognitive impairment. The diagnosis is based on cognitive, neurological, and physical examination as well as analysis of blood samples, biomarkers, and genotype.
Total Tau reflects axonal disintegration. Tau constitutes cortical, unmyelinated axons where they bind to microtubules with a stabilizing effect. Total Tau can be used as a biomarker in Alzheimer's disease; increased levels can also be seen in other degenerative diseases of the brain and stroke.
Phospho-Tau (p-Tau) reflects the hyperphosphorylation of Tau and the formation of neurofibrils. P-tau has a reduced ability to bind microtubules, which leads to impaired axonal stability. Elevated levels of Phospho-Tau are typical in Alzheimer's disease but rarely in other conditions.
Beta-amyloid ratio 42/40 In Alzheimer's disease, Beta-amyloid 42 accumulates in plaques, which leads to a lower ratio of Beta-amyloid 42/40 and can be detected early in the course of the disease.
Tests included in panel
Need pricing information?
How to order
This test panel is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
CSF: At least 3 tubes x 0.5 mL CSF (polypropylene tubes).
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Send samples and request form
Within Sweden
Send samples frozen to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples frozen to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2025-08-18
