INDIVIDUAL TEST 997-L

Beta amyloid ratio 42/40

Indication

In memory investigation, Alzheimer's disease

Method

Chemiluminescence 

Response

The result is reported as a ratio

Interpretation

Beta amyloid 40 is the most common variant of beta amyloid in CSF, while beta amyloid 42 predominates in senile plaques. Decreased ratio of Beta amyloid 42/40 is a strong marker of Alzheimer's disease and can be detected early in the disease progression, even before clinical dementia occurs.

References

  • Hansson O, Lehmann S, Otto M, Zetterberg H, Lewczuk P. Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease. Alzheimers Res Ther. 2019;11(1):34. PMID: 31010420
  • Dumurgier J, Schraen S, Gabelle A, et al. Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study. Alzheimers Res Ther. 2015;7(1):30. PMID: 26034513

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Neurology

ENSKILD ANALYS 997-L

Beta amyloid kvot 42/40

Indikation

Vid minnesutredning, Alzheimer’s sjukdom

Metod

Kemiluminescens

Svar

Svaret rapporteras som en kvot

Tolkning

Beta amyloid 40 är den mest förekommande varianten av beta amyloid i likvor, men beta amyloid 42 dominerar i senila plaques. Sänkt kvot Beta amyloid 42/40 i likvor kan påvisas redan tidigt i sjukdomsförloppet av Alzheimers sjukdom, även innan klinisk demens föreligger och är av värde för att urskilja Alzheimer från andra former av demens. 

Referenser

  • Hansson O, Lehmann S, Otto M, Zetterberg H, Lewczuk P. Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease. Alzheimers Res Ther. 2019;11(1):34. PMID: 31010420
  • Dumurgier J, Schraen S, Gabelle A, et al. Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study. Alzheimers Res Ther. 2015;7(1):30. PMID: 26034513

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