DIAGNOSTIC TEST 925

C1 INH Level

Diagnostic test for C1-INH level. For investigation of angioedema.

Indication

Suspicion of of angioedema

Sample material

EDTA-plasma

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: frozen
  • International: frozen

Method

Nephelometry

Reference interval

0.16-0.36 g/L

Result

The result is reported as normal, low, or elevated with a concentration (g/L).

Interpretation

Elevated concentration of C1-inhibitor can be seen in hereditary angioedema (HAE) type 2. Further test of C1-inhibitor function is recommended if HAE type 2 is suspected.

Low levels of C1-inhibitor may indicate hereditary angioedema (HAE) type 1 or consumption of C1-inhibitor (may be seen in some malignancies). The result should primarily be verified with a new sample as well as to include analysis of the concentration of C4.

A test of C1-inhibitor function is recommended if hereditary angioedema (HAE) type 2 is suspected after normal C1 levels.

References

  • Maurer M et al. World Allergy Organ J. 2022. The international WAO/EAACI guideline for the management of hereditary angioedema - The 2021 revision and update. PMID: 35497649

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    EDTA Plasma: At least 0.5 mL blood plasma (EDTA tubes).

  3. Send samples and request form

    Within Sweden
    Send samples frozen to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples frozen to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-12-05