DIAGNOSTIC TEST 003

NF155 Antibodies (IgG)

Diagnostic test for antibodies against NF155 (IgG). For suspicion of inflammatory neuropathy/autoimmune nodopathy.

Indication

Suspicion of inflammatory neuropathy/autoimmune nodopathy

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

<1:10 negative

Result

Results are reported as negative or positive. A positive result is followed by a titer.

Interpretation

Neurofascin-155 (NF155) is a paranodal protein. IgG antibodies against NF155 have been reported in autoimmune nodopathy. The simultaneous presence of antibodies against NF155 and NF186 is seen in pan-neurofascin nodopathy.

References

  • Van den Bergh PYK et al. J Peripher Nerv Syst. 2021. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision. PMID: 34085743
  • Dong M et al. Clin Neurol Neurosurg. 2022. Characterization of the patients with antibodies against nodal-paranodal junction proteins in chronic inflammatory demyelinating polyneuropathy. PMID: 36401951
  • Querol LA et al. Neurotherapeutics. 2022. The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies. PMID: 35378684
  • Cortese A et al. Neurol Neuroimmunol Neuroinflamm. 2019. Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype. PMID: 31753915
  • Delmont E et al. Brain. 2017. Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. PMID: 28575198
  • Appeltshauser L et al. Brain. 2023. Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage. PMID: 36346134

Included in these panels

Need pricing information?

Get a quote

How to order

This test is only available as part of a test panel.

Last updated: 2026-09-30