Svar Life Science
Reliable Assessment of Antibody-Driven
AAV Immunogenicity
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Gene Therapy Solutions

We offers solutions within functional bioassays, both cell based and Ligand binding, Immunogenicity assessment and Mode of Action reflecting cell based potency assays. We also offer solutions for AAV induced complement activation – all intended to support your analytical needs within every phase of the drug development continuum.

Download our latest scientific posters

Discover how integrating immuno- and cell-based methods meets the critical need in AAV-mediated gene therapy development by accurately assessing NAbs and TAbs, while also gaining insights into predictive immunogenicity assessment and the importance of comprehensive patient response evaluation.

COMPREHENSIVE IMMUNOGENICITY ANALYSIS OF AAV THERAPIES:

Correlating Anti-AAV Antibodies (NAbs/TAbs) with Complement Activation Dynamics

Celik S, Kulak K, Kozma V, Klint C, Vallette B, Nilsson C, Lallemand C, Tovey M, Bovin L F, Butler S, Schwenkert M, Rodo J

Learn more about how combining immuno- and cell-based methodologies, effectively addresses the crucial demand in the clinical development of AAV-mediated gene therapies by providing precise assessments of NAbs and TAbs.

S-140-GB00 - NAbs, TAbs, Compl. AAV - ASGCT 2024 Poster, 36x72 in, FINAL-1

ELUCIDATING COMPLEMENT ACTIVATION MECHANISMS IN AAV GENE THERAPY:

Development of a Novel ELISA-Based Assay for Enhanced Safety and Efficacy

Kulak K, Kozma V, Klint C, Nilsson C , Butler S, Schwenkert M, Rodo J

Gain deeper insights into the predictive assessment of AAV-mediated immunogenicity and how understanding and evaluating patient responses to AAV-mediated gene therapy comprehensively is crucial.

S-139-GB00 - Compl. AAV - ASGCT 2024 Poster, 36x72 in-LOW-1

Download our Scientific Posters here

Please fill out the form below to access the download link.

So, how can we ensure your gene therapy project reaches its full potential?

By harnessing the power of our robust analytical platforms and drawing on the insights gained from our diagnostic and bioanalytical services, we can help you tackle the challenges of creating bioassays tailored specifically for your gene therapy projects. Collaborating closely with major clients, we have specialized in customizing cell-based and immunoassays for potency testing and immunogenicity assessment, precisely tailored to meet the unique needs of your project.

Gene therapy presents a host of analytical challenges not typically encountered with conventional biopharmaceutical products. From assessing product potency to the presence of anti-AAV antibodies (NAb/TAb) our expertise ensures you're equipped to navigate these complexities with confidence. Curious to learn more about how Svar can support your gene therapy projects? Don't hesitate to reach out!

Curious to learn more about how Svar can support your gene therapy projects?

Don't hesitate to reach out!