INDIVIDUAL TEST 002
GBM Antibodies (IgG)
Indication
Suspicion of Goodpasture syndrome
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: room temperature
Method
FEIA (fluoroenzyme immunoassay)
Reference interval
< 7 U/mL negative, 7–10 U/mL borderline
Result
Results are reported as negative, borderline, or positive with a concentration.
Interpretation
Goodpasture syndrome is characterized by a rapidly progressive glomerulonephritis. Lung commitment with bleeding is also common. The antibodies target the type IV collagen of the basal membranes of the glomeruli and lung capillaries. Early diagnosis and a prompt treatment are crucial to avoid irreversible tissue damage. The antibody levels can be used to monitor treatment effect.
If suspicion of Goodpasture syndrome remains despite a borderline result, then subtyping determination of IgG4-antibodies against GBM is recommended. Contact the laboratory if this test is wished.
References
- Hudson BG et al. N Engl J Med. 2003. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. PMID: 12815141
- Segelmark M et al. Nephron Clin Pract. 2003. The prognostic significance in Goodpasture's disease of specificity, titre and affinity of anti-glomerular-basement-membrane antibodies. PMID: 12902632
- Rovin BH et al. Kidney Int. 2021. Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases. PMID: 34556300
Last updated: 2025-10-09
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ENSKILD ANALYS 002
GBM-antikroppar (IgG)
Indikation
Misstanke om anti-GBM-sjukdom (Goodpasture syndrome)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: rumstemperatur
Metod
FEIA (fluoroenzymeimmunoassay)
Referensintervall
< 7 U/mL negativt, 7–10 U/mL gränsvärde
Resultat
Resultatet anges som negativt, gränsvärde eller positivt med koncentration.
Tolkning
Anti-GBM-sjukdom (Goodpasture syndrom) karakteriseras av snabbt progredierande glomerulonefrit. Lungengagemang med alveolär blödning är också vanligt. Antikropparna är riktade mot typ IV kollagen i njurglomerulis och lungkapillärernas basalmembran. Tidig diagnos och snabbt insatt behandling är avgörande för att undvika irreversibla vävnadsskador. Antikroppsnivån kan användas för att följa behandlingseffekt.
Om diagnosen misstänks trots gränsvärde kan vidare subklassbestämning av IgG4-antikroppar mot GBM vara av värde. Kontakta laboratoriet om detta test önskas.
Referenser
- Hudson BG et al. N Engl J Med. 2003. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. PMID: 12815141
- Segelmark M et al. Nephron Clin Pract. 2003. The prognostic significance in Goodpasture's disease of specificity, titre and affinity of anti-glomerular-basement-membrane antibodies. PMID: 12902632
- Rovin BH et al. Kidney Int. 2021. Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases. PMID: 34556300
Senast uppdaterat: 2025-10-09