INDIVIDUAL TEST 025

Sm Antibodies

Indication

Suspicion of systemic lupus erythematosus

Sample material

Serum

• Minim. volume: 0,5 mL

Transport

Within Sweden

• room temperature

International

• cold

Method

Immunoblot

Reference interval

• ≤10 negative

Result

Results are reported as negative or positive with an intensity value. Positive results are confirmed with ELISA.

Interpretation

Anti-Sm antibodies are markers for systemic lupus erythematosus.

References

• Tomer Y et al. Int Arch Allergy Immunol. 1993. Pathogenic significance and diagnostic value of lupus autoantibodies. PMID: 8481649
• von Mühlen CA, Tan EM. Semin Arthritis Rheum. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. PMID: 7604300
• Van Duijnhoven HL et al. Clin Biochem. 1999. A comparison of ELISA assays as routine diagnostic test for detection of autoantibodies against extractable nuclear antigens. PMID: 10383077
• Hiepe F et al. Int Arch Allergy Immunol. 2000. Antinuclear antibody- and extractable nuclear antigen-related diseases. PMID: 11014966
• Mahler M et al. Clin Immunol. 2003. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. PMID: 12763475
• Hennes EM et al. Hepatology. 2008. Simplified criteria for the diagnosis of autoimmune hepatitis. PMID: 18537184
• Damoiseaux J et al. Ann Rheum Dis. 2019. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. PMID: 30862649

Last updated: 2024-10-22