INDIVIDUAL TEST 028
SSB/La Antibodies
Indication
Suspicion of Sjogren's syndrome and systemic lupus erythematosus
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot
Reference interval
- ≤10 negative
Result
Results are reported as negative or positive with an intensity value. Positive results are confirmed with ELISA.
Interpretation
Anti-SSB (La) antibodies occur almost always in conjunction with anti-SSA and are seen above all in primary Sjogren's syndrome and systemic lupus erythematosus. Antibodies against SSB (La) are also associated with small fiber neuropathy. The clinical relevance of isolated anti-SSB antibodies is unclear.
References
- Tomer Y et al. Int Arch Allergy Immunol. 1993. Pathogenic significance and diagnostic value of lupus autoantibodies. PMID: 8481649
- von Mühlen CA, Tan EM. Semin Arthritis Rheum. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. PMID: 7604300
- Van Duijnhoven HL et al. Clin Biochem. 1999. A comparison of ELISA assays as routine diagnostic test for detection of autoantibodies against extractable nuclear antigens. PMID: 10383077
- Hiepe F et al. Int Arch Allergy Immunol. 2000. Antinuclear antibody- and extractable nuclear antigen-related diseases. PMID: 11014966
- Mahler M et al. Clin Immunol. 2003. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. PMID: 12763475
- Hennes EM et al. Hepatology. 2008. Simplified criteria for the diagnosis of autoimmune hepatitis. PMID: 18537184
- Damoiseaux J et al. Ann Rheum Dis. 2019. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. PMID: 30862649
Last updated: 2024-10-22
Can't find what you're looking for? We are here to help
ENSKILD ANALYS 028
SSB/La-antikroppar
Indikation
Misstanke om Sjögrens syndrom och systemisk lupus erytematosus
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot
Referensintervall
- ≤10 negativt
Resultat
Resultat anges som negativt eller positivt med intensitetsvärde. Positivt resultat bekräftas med ELISA.
Tolkning
Anti-SSB (La) förekommer nästan alltid tillsammans med anti-SSA och ses framför allt vid primärt Sjögrens syndrom och systemisk lupus erytematosus. Antikroppar mot SSB (La) är även associerade med fintrådsneuropati. Isolerad förekomst av anti-SSB har ingen känd klinisk betydelse.
Referenser
- Tomer Y et al. Int Arch Allergy Immunol. 1993. Pathogenic significance and diagnostic value of lupus autoantibodies. PMID: 8481649
- von Mühlen CA, Tan EM. Semin Arthritis Rheum. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. PMID: 7604300
- Van Duijnhoven HL et al. Clin Biochem. 1999. A comparison of ELISA assays as routine diagnostic test for detection of autoantibodies against extractable nuclear antigens. PMID: 10383077
- Hiepe F et al. Int Arch Allergy Immunol. 2000. Antinuclear antibody- and extractable nuclear antigen-related diseases. PMID: 11014966
- Mahler M et al. Clin Immunol. 2003. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. PMID: 12763475
- Hennes EM et al. Hepatology. 2008. Simplified criteria for the diagnosis of autoimmune hepatitis. PMID: 18537184
- Damoiseaux J et al. Ann Rheum Dis. 2019. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. PMID: 30862649
Senast uppdaterat: 2024-10-22