Ribosomal RNP (rRNP and P-protein) antibodies

IndicationSuspicion of systemic lupus erythematosus, especially with CNS involvement.MethodELISA with purified proteins. The antibodies react with three phosphoproteins of 38, 19 and 17 kD, which are all bound to ribosomal RNA.AnswerThe result is given as positive or negative.InterpretationPositive in about 10% of patients with systemic lupus erythematosus, especially in lupus manifestations in the central nervous system.


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Autoimmune diagnostics


Ribosomalt RNP/rRNP/P-protein-antikroppar

IndikationMisstanke om systemisk lupus erytematosus, speciellt vid CNS engagemang.MetodELISA med upprenade proteiner. Antikropparna reagerar med tre fosfoproteiner på 38, 19 och 17kD, som alla är bundna till ribosomalt RNA.SvarResultatet anges som positivt eller negativt.TolkningPositivt hos ca 10% av patienter med systemisk lupus erytematosus, speciellt vid lupus manifestationer i centrala nervsystemet.

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