INDIVIDUAL TEST 032
SSA/Ro52 Antibodies
Indication
Suspicion of autoimmune disease and congenital AV-block/cardiac arrhythmia in fetus
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot
Reference interval
- ≤10 negative
Result
Results are reported as negative or positive with an intensity value.
Interpretation
Anti-SSA/Ro52 is associated with several autoimmune conditions such as rheumatic diseases, inflammatory myositis, and autoimmune liver disease.
During pregnancy, anti-SSA/Ro52 is associated with congenital AV-block/cardiac arrhythmia in the fetus. In women with known SLE/Sjögrens syndrome, the risk of this is estimated to be around 3%. The risk of mothers with these antibodies but without rheumatic disease is unknown but is believed to be lower. For early diagnosis of AV-block, weekly monitoring of the fetal heart rhythm is recommended between 18-24 weeks of gestation.
References
- Tomer Y et al. Int Arch Allergy Immunol. 1993. Pathogenic significance and diagnostic value of lupus autoantibodies. PMID: 8481649
- von Mühlen CA, Tan EM. Semin Arthritis Rheum. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. PMID: 7604300
- Van Duijnhoven HL et al. Clin Biochem. 1999. A comparison of ELISA assays as routine diagnostic test for detection of autoantibodies against extractable nuclear antigens. PMID: 10383077
- Hiepe F et al. Int Arch Allergy Immunol. 2000. Antinuclear antibody- and extractable nuclear antigen-related diseases. PMID: 11014966
- Mahler M et al. Clin Immunol. 2003. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. PMID: 12763475
- Hennes EM et al. Hepatology. 2008. Simplified criteria for the diagnosis of autoimmune hepatitis. PMID: 18537184
- Damoiseaux J et al. Ann Rheum Dis. 2019. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. PMID: 30862649
Last updated: 2024-10-22
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ENSKILD ANALYS 032
SSA/Ro52 -antikroppar
Indikation
Misstanke om autoimmun sjukdom, samt utveckling av hjärtblock hos foster till gravida kvinnor
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot
Referensintervall
- ≤10 negativt
Resultat
Resultat anges som negativt eller positivt med intensitetsvärde.
Tolkning
Anti-SSA/Ro52 är associerat med flera autoimmuna tillstånd såsom reumatiska sjukdomar, inflammatorisk myosit och autoimmun leversjukdom.
Vid graviditet är anti-SSA/Ro52 associerat med kongenitalt AV-block/hjärtrytmrubbning hos fostret. Hos kvinnor med känd SLE/Sjögrens syndrom uppskattas risken för detta vara omkring 3%. Risken för mödrar med dessa antikroppar men utan reumatisk sjukdom är okänd, men tros vara lägre. För tidig diagnostik av AV-block rekommenderas veckovis uppföljning av fostrets hjärtrytm under graviditetsveckorna 18-24.
Referenser
- Tomer Y et al. Int Arch Allergy Immunol. 1993. Pathogenic significance and diagnostic value of lupus autoantibodies. PMID: 8481649
- von Mühlen CA, Tan EM. Semin Arthritis Rheum. 1995. Autoantibodies in the diagnosis of systemic rheumatic diseases. PMID: 7604300
- Van Duijnhoven HL et al. Clin Biochem. 1999. A comparison of ELISA assays as routine diagnostic test for detection of autoantibodies against extractable nuclear antigens. PMID: 10383077
- Hiepe F et al. Int Arch Allergy Immunol. 2000. Antinuclear antibody- and extractable nuclear antigen-related diseases. PMID: 11014966
- Mahler M et al. Clin Immunol. 2003. Advances in B-cell epitope analysis of autoantigens in connective tissue diseases. PMID: 12763475
- Hennes EM et al. Hepatology. 2008. Simplified criteria for the diagnosis of autoimmune hepatitis. PMID: 18537184
- Damoiseaux J et al. Ann Rheum Dis. 2019. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. PMID: 30862649
Senast uppdaterat: 2024-10-22