INDIVIDUAL TEST 052

Dopamin-2 receptor (D2R) antibodies

IndicationSuspicion of autoimmune encephalitis.

MethodIndirect immunofluorescence. The method is not yet validated.

ResponseReported as negative or positive with titer.
Can be tested in serum and CSF.

InterpretationAutoantibodies against Dopamine-2 receptor (D2R) have been reported in a few cases of pediatric autoimmune encephalitis. Typical clinical features in children are encephalitis with predominant movement disorders, psychiatric symptoms, sleep disturbance, mutism, and decreased consciousness.

Referenser

  1. Cellucci T et al. Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient. Neurol Neuroimmunol Neuroinflamm 2020;7:e663. PMID: 31953309 
  2. Sinmaz N et al. Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders. Acta Neuropathologica Communications (2016) 4:126. PMID: 27908295 
  3. Pathmanandavel K et al. Antibodies to Surface dopamine-2 Receptor and N-methyl-D-aspartate Receptor in the First Episode of Acute Psychosis in Children. Biological Psychiatry March 15, 2015; 77:537–547. PMID: 25168608 
  4. Dale R C et al. Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders. Brain 2012: 135; 3453–3468. PMID: 23065479 

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Neurology

ENSKILD ANALYS 052

Dopamin-2 receptor (D2R) antikroppar

IndikationMisstanke om autoimmun encefalit. 

MetodIndirekt immunofluorescens. Metoden är ännu inte validerad.

SvarAnges som negativ eller positiv med titer.
Kan testas i serum och likvor.

TolkningAutoantikroppar mot Dopamin-2-receptor (D2R) har rapporterats i ett fåtal fall av pediatrisk autoimmun encefalit. Typiska kliniska bilder hos barn är encefalit med dominerande rörelsestörningar, psykiatriska symptom, sömnstörningar, mutism och sänkt medvetande.

Referenser

  1. Cellucci T et al. Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient. Neurol Neuroimmunol Neuroinflamm 2020;7:e663. PMID: 31953309 
  2. Sinmaz N et al. Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders. Acta Neuropathologica Communications (2016) 4:126. PMID: 27908295 
  3. Pathmanandavel K et al. Antibodies to Surface dopamine-2 Receptor and N-methyl-D-aspartate Receptor in the First Episode of Acute Psychosis in Children. Biological Psychiatry March 15, 2015; 77:537–547. PMID: 25168608 
  4. Dale R C et al. Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders. Brain 2012: 135; 3453–3468. PMID: 23065479

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