INDIVIDUAL TEST 084
Mitochondrial Antibodies (AMA)
Indication
Suspicion of Suspicion of primary biliary cholangitis (PBC) or autoimmune hepatitis
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Indirect immunofluorescence (IIF)
Reference interval
<1:100 negative
Result
Results are reported as negative or positive with a titer.
Interpretation
AMA type M2 is a strong marker for established or future development of primary biliary cholangitis (PBC) and occurs in about 90% of the cases. PBC is a chronic autoimmune disease that affects the intrahepatic bile ducts resulting in cholestasis.
References
- European Association for the Study of the Liver. J Hepatol. 2025. EASL Clinical Practice Guidelines on the management of autoimmune hepatitis. PMID: 40348684
- Marschall HU et al. Sci Rep. 2019. Incidence, prevalence, and outcome of primary biliary cholangitis in a nationwide Swedish population-based cohort. PMID: 31395896
Last updated: 2025-11-19
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ENSKILD ANALYS 084
Mitokondrie-antikroppar (AMA)
Indikation
Misstanke om primär biliär cholangit (PBC) eller autoimmun hepatit
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Indirekt immunofluorescens (IIF)
Referensintervall
<1:100 negativt
Resultat
Resultat anges som negativt eller positivt med titer.
Tolkning
AMA typ M2 är en stark markör för manifest eller framtida utveckling av primär biliär cholangit (PBC) och förekommer i drygt 90% av fallen. PBC är en kronisk autoimmun sjukdom som drabbar de intrahepatiska gallgångarna med kolestas som följd.
Referenser
- European Association for the Study of the Liver. J Hepatol. 2025. EASL Clinical Practice Guidelines on the management of autoimmune hepatitis. PMID: 40348684
- Marschall HU et al. Sci Rep. 2019. Incidence, prevalence, and outcome of primary biliary cholangitis in a nationwide Swedish population-based cohort. PMID: 31395896
Senast uppdaterat: 2025-11-19