Vial

INDIVIDUAL TEST 085

Striational Antibodies

Indication

Suspicion of myasthenia gravis and thymoma.

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Method

Indirect immunofluorescence (IIF)

Reference interval

<1:20 negative

Result

Results are reported as negative or positive with a fluorescence intensity.

Interpretation

Antibodies against striated muscle are primarily associated with Myasthenia Gravis (MG) with onset after age 50 (late-onset MG) but can also be seen at thymoma. Please contact the laboratory if a follow-up analysis of antibodies against Titin is desired.

Autoantibodies against striated muscle may be mild positive in chronic muscular diseases such as polymyositis, muscle dystrophy, and fibromyalgia.

References

  • Graus YM, De Baets MH. Immunol Res. 1993. Myasthenia gravis: an autoimmune response against the acetylcholine receptor. PMID: 7685805
  • Atassi MZ. Molecular recognition of acetylcholine receptor. Adv Neuroimmunol. 1994. Recognition by alpha-neurotoxins and by immune and autoimmune responses and manipulation of the responses. PMID: 7536603
  • Hardy EM, Rittenberry K. Orthop Nurs. 1994. Myasthenia gravis: an overview. PMID: 7870479
  • Marx A et al. Virchows Arch. 1997. Pathogenesis of myasthenia gravis. PMID: 9174625
  • Lübke E et al. J Neuroimmunol. 1998. Striational autoantibodies in myasthenia gravis patients recognize I-band titin epitopes. PMID: 9521611
  • Romi F et al. J Neurol. 2000. Muscle autoantibodies in subgroups of myasthenia gravis patients. PMID: 10896269

Last updated: 2024-06-26

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Vial

ENSKILD ANALYS 085

Tvärstrimmig muskel-antikroppar

Indikation

Misstanke om Myastenia gravis och thymom

Provmaterial

Serum

  • Minim. volym: 0,5 mL

Transport

Inom Sverige

  • rumstemperatur

Internationellt

  • kylt

Metod

Indirekt immunofluorescens (IIF)

Referensintervall

<1:20 negativt

Resultat

Resultat anges som negativt eller positivt med styrka på fluorescensintensitet.

Tolkning

Antikroppar mot tvärstrimmig muskel är i första hand associerade med Myastenia Gravis (MG) som debuterar efter 50 års ålder (late onset MG), men kan även ses vid tymom. Var god kontakta laboratoriet om uppföljning med analys av antikroppar mot Titin önskas.

Autoantikroppar mot tvärstrimmig muskel kan vara svagt positiv vid kroniska muskelsjukdomar som polymyosit, muskeldystrofi och fibromyalgi.

Referenser

  • Graus YM, De Baets MH. Immunol Res. 1993. Myasthenia gravis: an autoimmune response against the acetylcholine receptor. PMID: 7685805
  • Atassi MZ. Molecular recognition of acetylcholine receptor. Adv Neuroimmunol. 1994. Recognition by alpha-neurotoxins and by immune and autoimmune responses and manipulation of the responses. PMID: 7536603
  • Hardy EM, Rittenberry K. Orthop Nurs. 1994. Myasthenia gravis: an overview. PMID: 7870479
  • Marx A et al. Virchows Arch. 1997. Pathogenesis of myasthenia gravis. PMID: 9174625
  • Lübke E et al. J Neuroimmunol. 1998. Striational autoantibodies in myasthenia gravis patients recognize I-band titin epitopes. PMID: 9521611
  • Romi F et al. J Neurol. 2000. Muscle autoantibodies in subgroups of myasthenia gravis patients. PMID: 10896269

Senast uppdaterat: 2024-06-26

Mer information

Detta är en ackrediterad analys.
> Läs mer [.pdf]

Mer information om provtagning.
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