INDIVIDUAL TEST 086
Adrenal Cortex Antibodies
Indication
Suspicion of primary Addison’s disease (idiopathic adrenal cortex insufficiency)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Indirect immunofluorescence (IIF)
Reference interval
<1:20 negative
Result
Results are reported as negative or positive with fluorescence intensity.
Interpretation
Antibodies against adrenal cortex are detected in about 70% of patients with primary adrenal cortex insufficiency which is more common in women and associated with other autoimmune diseases, e.g. Hashimoto’s thyroiditis, juvenile diabetes mellitus or pernicious anemia. Analysis of autoantibodies against 21-hydroxylas is to be preferred since they are a more sensitive and more specific marker for this disease.
References
- Nikoshkov A et al. J Immunol. 1999. A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase. PMID: 9973524
- Falorni A et al. Fertil Steril. 2002. Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity. PMID: 12137862
- Saverino S, Falorni A. Best Pract Res Clin Endocrinol Metab. 2020 Autoimmune Addison's disease. PMID: 32063488
Last updated: 2025-10-10
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ENSKILD ANALYS 086
Binjurebark-antikroppar
Indikation
Misstanke om primär Addisons sjukdom (idiopatisk binjurebarksinsufficens)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Indirekt immunofluorescens (IIF)
Referensintervall
<1:20 negativt
Resultat
Resultat anges som negativt eller positivt med fluorescensens styrka.
Tolkning
Antikroppar mot binjurebark påvisas hos ca. 70% av patienter med primär binjurebarksinsufficiens som är vanligare hos kvinnor och ofta associerat med andra autoimmuna sjukdomar t.e.x. Hashimoto’s thyreoidit, juvenil diabetes mellitus eller perniciös anemi. I första hand rekommenderas analys av antikroppar mot 21-hydroxylas som är en känsligare och mer specifik markör för denna sjukdom.
Referenser
- Nikoshkov A et al. J Immunol. 1999. A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase. PMID: 9973524
- Falorni A et al. Fertil Steril. 2002. Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity. PMID: 12137862
- Saverino S, Falorni A. Best Pract Res Clin Endocrinol Metab. 2020 Autoimmune Addison's disease. PMID: 32063488
Senast uppdaterat: 2025-10-10