INDIVIDUAL TEST 087

Parietal Cell Antibodies

IndicationSuspicion of pernicious anemia and atrophic gastritis.MethodIndirect immunofluorescence (IIF)AnswerThe result is given as negative or positive with a titer.InterpretationAntibodies against parietal cells occur in atrophic gastritis and are detected in approximately 85% of patients with pernicious anemia. The antibodies also occur in 25% of the cases with autoimmune thyroid disease, which is often associated with atrophic gastritis.