INDIVIDUAL TEST 090
Islet Cell Antibodies
Indication
Suspicion of type 1 diabetes (T1D)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: room temperature
Method
Indirect immunofluorescence (IIF)
Reference interval
<1:5 negative
Result
Results are reported as negative or positive with a titer.
Interpretation
Approximately 70-90% of patients diagnosed with T1D, are positive for antibodies against Islet cells. Antibodies can be detected several years before diagnosis and are a strong predictor of future development of insulin-dependent diabetes mellitus (IDDM).
Islet cell antibodies comprise of a heterogeneous group of antibodies that are directed against glutamic acid decarboxylase (GAD65), tyrosine phosphatase-related islet cell antigen 2 (IA-2), zinc transport protein ZnT8, and other untill now unknown antigens.
References
- Hill TG, Hill DJ. Int J Mol Sci. 2024 The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. PMID: 38612880
- Joglekar MV et al. Lancet Diabetes Endocrinol. 2024 Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores. PMID: 38797187
- Phillip M et al. Diabetes Care. 2024. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. PMID: 38912694
Last updated: 2025-11-19
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ENSKILD ANALYS 090
Ö-cells-antikroppar
Indikation
Misstanke om typ 1 diabetes (T1D)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Indirekt immunofluorescens (IIF)
Referensintervall
< 1:5 negativt
Resultat
Resultat anges som negativt eller positivt med titer.
Tolkning
Vid diagnos av T1D kan antikroppar mot Langerhanska ö-celler påvisas hos 70–90% av patienterna. Antikropparna kan förekomma flera år före diagnos och är en stark prediktor för framtida utveckling av insulinberoende diabetes mellitus (IDDM).
Ö-cellsantikroppar utgörs av en heterogen grupp av antikroppar som kan vara riktade mot glutaminsyradekarboxylas (GAD65), tyrosinfosfatas relaterat ö-cellsantigen 2 (IA-2), zinktransport proteinet ZnT8 och andra hittills okända antigen.
Referenser
- Hill TG, Hill DJ. Int J Mol Sci. 2024 The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. PMID: 38612880
- Joglekar MV et al. Lancet Diabetes Endocrinol. 2024 Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores. PMID: 38797187
- Phillip M et al. Diabetes Care. 2024. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. PMID: 38912694
Senast uppdaterat: 2025-11-19