INDIVIDUAL TEST 093
MAG Antibodies
Indication
Suspicion of Inflammatory neuropathy
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
ELISA
Reference interval
Serum
- < 30 % negative
CSF
- < 1000 U/mL negative
Result
Serum
- results are reported as negative, borderline, or positive with a value
CSF
- results are reported as negative or positive with a value
Interpretation
Myelin-associated glycoprotein (MAG) is a transmembrane glycoprotein that is located in the myelin skins adjacent to the axon. MAG constitutes a very small part (0.1-1%) of the total protein content of myelin.
Several different forms of motor and sensory neuropathies have been shown to be associated with IgM antibodies to MAG. High levels of antibodies against MAG have been observed in demyelinating motor and sensory neuropathies, low levels have been reported in multiple sclerosis, inflammatory neuropathies and motor neuron diseases. About half of the patients with monoclonal IgM gammopathies with associated neuropathy have antibodies against MAG. The antibodies are usually detected in serum but can also be seen in CSF. Borderline result has uncertain clinical relevance.
References
- Jacobs BC et al. IGOS Consortium. J Peripher Nerv Syst. 2017. International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome. PMID: 28406555
- Shang P et al. J Neurol. 2021. Axonal variants of Guillain-Barré syndrome: an update. PMID: 32140865
- Sheikh AB et al. J Neuroimmunol. 2021. Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review. PMID: 33895700
- Van den Bergh PYK et al. J Peripher Nerv Syst. 2021. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision. PMID: 34085743
- Wijdicks EF, Klein CJ. Mayo Clin Proc. 2017. Guillain-Barré Syndrome. PMID: 28259232
- Willison HJ et al. Lancet. 2016. Guillain-Barré syndrome. PMID: 26948435
Last updated: 2024-08-13
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ENSKILD ANALYS 093
MAG-antikroppar
Indikation
Misstanke om Inflammatorisk neuropati
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
ELISA
Referensintervall
Serum
- < 30 % negativt
Likvor
- <1000 U/mL negativt
Resultat
Serum
- resultat anges som negativt, gränsvärde eller positivt med värde.
Likvor
- resultat anges som negativt eller positivt med ett värde.
Tolkning
Myelinassocierat glykoprotein (MAG) är ett transmembran glykoprotein som är lokaliserat i myelinskidorna i anslutning till axonet. MAG utgör en mycket liten del (0,1-1%) av det totala proteininnehållet i myelin. Flera olika former av sensoriska och sensorimotoriska neuropatier har visats vara associerade med IgM-antikroppar mot MAG.
Hög nivå av antikroppar mot MAG har observerats vid demyeliniserande sensorimotoriska neuropatier. Omkring hälften av patienterna med monoklonal IgM-gammopati med associerad neuropati har antikroppar mot MAG. Antikropparna påvisas vanligen i serum, men kan ibland även ses i CSF. Gränsvärden har tveksam klinisk betydelse.
Referenser
- Jacobs BC et al. IGOS Consortium. J Peripher Nerv Syst. 2017. International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome. PMID: 28406555
- Shang P et al. J Neurol. 2021. Axonal variants of Guillain-Barré syndrome: an update. PMID: 32140865
- Sheikh AB et al. J Neuroimmunol. 2021. Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review. PMID: 33895700
- Van den Bergh PYK et al. J Peripher Nerv Syst. 2021. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision. PMID: 34085743
- Wijdicks EF, Klein CJ. Mayo Clin Proc. 2017. Guillain-Barré Syndrome. PMID: 28259232
- Willison HJ et al. Lancet. 2016. Guillain-Barré syndrome. PMID: 26948435
Senast uppdaterat: 2024-08-13