MAG Antibodies

IndicationSuspicion of Inflammatory neuropathy.MethodELISA AnswerThe result is given as negative or positive with a value.InterpretationMyelin-associated glycoprotein (MAG) is a transmembrane glycoprotein that is located in the myelin skins adjacent to the axon. MAG constitutes a very small part (0.1-1%) of the total protein content of myelin.

Several different forms of motor and sensory neuropathies have been shown to be associated with IgM antibodies to MAG. High levels of antibodies against MAG have been observed in demyelinating motor and sensory neuropathies, low levels have been reported in multiple sclerosis, inflammatory neuropathies and motor neuron diseases. About half of the patients with monoclonal IgM gammopathies with associated neuropathy have antibodies against MAG.

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IndikationMisstanke om Inflammatorisk neuropati.MetodELISASvarSvaret anges som negativt eller positivt med styrka/värde.TolkningMyelinassocierat glykoprotein (MAG) är ett transmembranöst glykoprotein som är lokaliserat i myelinskidorna i anslutning till axonet. MAG utgör en mycket liten del (0,1-1%) av det totala proteininnehållet i myelin. Flera olika former av sensoriska och sensorimotoriska neuropatier har visats vara associerade med IgM-antikroppar mot MAG.

Hög nivå av antikroppar mot MAG har observerats vid demyeliniserande sensorimotoriska neuropatier. Omkring hälften av patienterna med monoklonal IgM-gammopati med associerad neuropati har antikroppar mot MAG.

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