INDIVIDUAL TEST 100
GBM Antibodies (IgG4)
Indication
Follow-up analysis of Goodpasture’s syndrome, GPA, and other reno-pulmonary syndromes. It may indicate patients who should be monitored very closely and may predict relapses.
Method
ELISA with specific GP antigen and IgG4-subclass specific monoclonal antibodies. The test is performed on serum.
Result
The result is given as arbitrary units (units per mL). Reference interval: <7 units/mL negative.
Interpretation
Antibodies against GBM are usually dominated by IgG1, but all subclasses can be present. There have been reports of isolated presence of IgG4 subclass antibodies in cases with severe lung disease with or without mild kidney damage.
References
- Segelmark M et al. Antigen restriction and IgG subclasses among anti-GBM autoantibodies. Nephrol Dial Transplant. 1990;5(12):991-6. PMID: 2128958.
- Segelmark M, Wieslander J. IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA). Nephrol Dial Transplant. 1993;8(8):696-702. PMID: 8414154.
- Cohen Tervaert JW et al. Measurement og IgG3 levels of anti-proteinase 3 antibodies is useful in monitoring disease activity in Wegeners granulomatosis. JASN 1994, 5, 828.
- Boomsma MM et al. Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. Arthritis Rheum. 2000 Sep;43(9):2025-33. PMID: 11014352.
Last updated: 2024-06-18
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ENSKILD ANALYS 100
GBM antikroppar (IgG4)
Indikation
Uppföljningsprov vid Goodpasture syndrom, GPA samt andra renopulmonella syndrom. Kan indikera patienter som bör följas extra noga samt förutsäga återfall.
Metod
ELISA med specifika GP antigen och IgG4-subklass specifika monoklonala antikroppar. Analysen utförs i serum.
Resultat
Resultatet anges som arbiträra enheter (enheter/mL). Referensintervall: <7 enheter/mL negativt.
Tolkning
Antikroppar mot GBM domineras vanligen av IgG1, men alla subklasser kan förekomma. Isolerad förekomst av antikroppar av IgG4-subklass har rapporterats vid allvarlig lungpåverkan utan eller med mild njurskada.
Referenser
- Segelmark M et al. Antigen restriction and IgG subclasses among anti-GBM autoantibodies. Nephrol Dial Transplant. 1990;5(12):991-6. PMID: 2128958.
- Segelmark M, Wieslander J. IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA). Nephrol Dial Transplant. 1993;8(8):696-702. PMID: 8414154.
- Cohen Tervaert JW et al. Measurement og IgG3 levels of anti-proteinase 3 antibodies is useful in monitoring disease activity in Wegeners granulomatosis. JASN 1994, 5, 828.
- Boomsma MM et al. Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. Arthritis Rheum. 2000 Sep;43(9):2025-33. PMID: 11014352.
Senast uppdaterat: 2024-06-18