INDIVIDUAL TEST 100
GBM Antibodies (IgG4)
Indication
Follow-up analysis of Goodpasture’s syndrome, GPA, and other reno-pulmonary syndromes. It may indicate patients who should be monitored very closely and may predict relapses.
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
<7 U/mL negative
Result
Results are reported as negative or positive with concentration.
Interpretation
Antibodies against GBM are usually dominated by IgG1, but all subclasses can be present. Isolated presence of antibodies of IgG4 subclass have been reported in cases with severe lung disease with or without mild kidney damage.
References
- Segelmark M et al. Nephrol Dial Transplant. 1990. Antigen restriction and IgG subclasses among anti-GBM autoantibodies. PMID: 2128958
- Segelmark M, Wieslander J. Nephrol Dial Transplant. 1993. IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA). PMID: 8414154
- Boomsma MM et al. Arthritis Rheum. 2000. Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. PMID: 11014352
- Bharati J et al. Kidney Int Rep. 2023. Atypical Anti-Glomerular Basement Membrane Disease. PMID: 37284681
- Ohlsson S et al. Am J Kidney Dis. 2014. Circulating anti-glomerular basement membrane antibodies with predominance of subclass IgG4 and false-negative immunoassay test results in anti-glomerular basement membrane disease. PMID: 24189476
Last updated: 2025-10-09
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ENSKILD ANALYS 100
GBM antikroppar (IgG4)
Indikation
Uppföljningsprov vid Goodpasture syndrom, GPA samt andra renopulmonella syndrom. Kan indikera patienter som bör följas extra noga samt förutsäga återfall.
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
ELISA
Referensintervall
<7 U/mL negativt
Resultat
Resultat anges som negativt eller positivt med koncentration.
Tolkning
Antikroppar mot GBM domineras vanligen av IgG1, men alla subklasser kan förekomma. Isolerad förekomst av antikroppar av IgG4-subklass har rapporterats vid allvarlig lungpåverkan utan eller med mild njurskada.
Referenser
- Segelmark M et al. Nephrol Dial Transplant. 1990. Antigen restriction and IgG subclasses among anti-GBM autoantibodies. PMID: 2128958
- Segelmark M, Wieslander J. Nephrol Dial Transplant. 1993. IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA). PMID: 8414154
- Boomsma MM et al. Arthritis Rheum. 2000. Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study. PMID: 1101435
- Bharati J et al. Kidney Int Rep. 2023. Atypical Anti-Glomerular Basement Membrane Disease. PMID: 37284681
- Ohlsson S et al. Am J Kidney Dis. 2014. Circulating anti-glomerular basement membrane antibodies with predominance of subclass IgG4 and false-negative immunoassay test results in anti-glomerular basement membrane disease. PMID: 24189476
Senast uppdaterat: 2025-10-09